Mutations in mitochondrial DNA (mtDNA) associate with various disease states. A few mtDNA mutations strongly associate with diabetes, with the most common mutation being the A3243G mutation in the mitochondrial DNA-encoded tRNA( Leu , UUR ) gene.
((snip))
The molecular mechanism by which the A3243G mutation affects insulin secretion may involve an attenuation of cytosolic ADP/ATP levels leading to a resetting of the glucose sensor in the pancreatic β-cell((snip)). The origin of the age-dependent deterioration of pancreatic function in carriers of the A3243G mutation and the contribution of ATP and other mitochondrion-derived factors such as reactive oxygen species to the development of diabetes is discussed.
Source: Mitochondrial Diabetes
Very cool article. A friend of mine was asking me about type 2 diabetes and estrogen receptors.
And in trying to find her more information I stumbled across a variety of subjects and ultimately this paper.
It was particularly interesting to me because my wife had passed away from a medical condition that was at the time was thought to be a mitochondrial disease. With my microbiology background this both tore and fascinated me.
As I have pointed out in other posts blog post1 post2 it is likely if not probable that glyphosate the active ingredient in Roundup could be playing a role in America’s ongoing difficulties with type 2 diabetes. My friends poisons even “organic” / “green” / “natural” /etc, that are designed to kill other life-forms are probably not the best way of approaching the world.
The best to you all
Bob