I searched for LD50 bromethalin. LD50 is the amount of toxin given to a group where 50% of the test animals die. (L)ethal (D)ose 50
Take a group of 10 dogs and give them all concentration X . Take another group of 10 dogs give them concentration Y. Another group of 10 dogs get Z. Concentration X kills 9 of the dogs . Y kills 5 of the dogs. Z kills 4 dogs. 18 dogs have died without medical intervention or support therapy (pain medication) to give us Lethal Dose 50 Dog = Y. And they do it for cats, and mice, and rats, and bobwhite quail, other birds, male dogs vs female dogs, ….
There were relatively few hits but here are excerpts from some. No hits on aquatic or reptile. Which in some ways is a good thing at least those animals didn’t suffer and die. Why are these things approved with …. Sorry rhetorical question. I already know the answer it’s because the companies that produce and test this stuff are big moral Christian people who only have our best interest at heart.
http://toxnet.nlm.nih.gov/cgi-bin/sis/search/a?dbs+hsdb:@term+@DOCNO+6570
Ten random source male domestic short-hair cats, 2 to 6 yr old and 3.0-4.4 kg bw, were each given a single oral dose (1.5 mg/kg) of bromethalin (cat Nos. 1-5) or bait vehicle carrier (cat Nos. 6-10). Bromethalin-dosed cats developed a toxic syndrome characterized by ataxia, focal motor seizures, vocalization, decerebrate posture, decreased conscious proprioception, recumbency, depression, and semicoma. [Snip]… hypertrophied fibrous astrocytes, and hypertrophied oligodendrocytes were observed in the white matter of the cerebrum, cerebellum, brain stem, spinal cord, and optic nerve of all bromethalin-dosed cats.
Nine dogs given 6.25 mg bromethalin/kg po developed clinical signs and EEG abnormalities 15-58 hr postdosing. Predominant abnormal EEG changes included spike and spike-and-wave EEG patterns (66%), high voltage slow wave (HVSA, 50-150 microV, 1-6 Hz) activity (44%) photoconvulsive or photoparoxysmal irritative responses (44%), and marked voltage depression (dominant activity [Dorman DC et al; Vet Hum Toxicol 33 (1): 9-11 (1991)] **PEER REVIEWED**
LD50 for rats up to the 24th hr after swallowing the /EL614/ was 4.13 mg/kg, and it was 1.78 mg/kg at the 48th hr, and 1.32 mg/kg at the 72nd hr. Intoxication and death set in as the result of impaired function of almost all organs, which was explained by the lipidotropic action of the preparation. Particularly severe were the lesions (hemodynamic and degenerative) in the brain.
Dogs given a single oral dose of bromethalin at 6.25 mg/kg developed a toxic syndrome characterized by hyperexcitability, tremors, seizures, depression, and death within 15-63 hours after bromethalin admin. Gross lesions included mild cerebral edema (2/5) and mild pulmonary congestion (2/5). Histologic lesions included diffuse white matter spongiosis [Snip]…
In a second 90-day study, groups of 4 male and 4 female beagle dogs were orally dosed by gavage for 90 days at levels of 0, 5, 25, 125, or 200 ug/kg/day with bromethalin technical. Observations included daily clinical evaluations, ophthalmoscopy, body weight, food consumption, clinical pathology evaluations at weeks 6 and 13, necropsy, organ weights and histopathology. The NOEL is 25 g/kg/day. The LOEL is 125 g/kg/day based on spongy degeneration observed in nervous tissue components (cervical, thoracic, and lumbar spinal cord, brain stem, right and left optic nerves, frontal and median brain, pons, and cerebellum) in both sexes of dogs. At the high dose, 3 male dogs displayed the following neurotoxic signs before death or being sacrificed moribund: salivation and hypoactivity, followed by trembling, myoclonia, hyperesthesia, groaning, and decubitus. [Snip]…
LD50 Dog oral 4.8 mg/kg
[Krieger, R. (ed.). Handbook of Pesticide Toxicology. Volume 2, 2nd ed. 2001.LD50 Cat oral 18 mg/kg
[Krieger, R. (ed.). Handbook of Pesticide Toxicology. Volume 2, 2nd ed. 2001.LD50 Bobwhite quail oral 4.6-11.0 mg/kg /from table/
[USEPA; Reregistration Eligibility Decision Document – [Snip]…
I’m wondering if I can secede from the human race.